Liverpool, Sevilla and Borussia Dortmund booked their tickets for the quarter-finals of football's Europa League, eliminating Basel, Manchester United and Tottenham respectively.
Holders Sevilla, who have won the tournament four times since 2006, thumped Basel 3-0 to cruise through on a 3-0 aggregate, with a first-half brace from Kevin Gameiro after Adil Rami had headed them into the lead.
Liverpool battled out a creditable 1-1 draw at historic rivals United to go through comfortably 3-1.
Anthony Martial gave United the lead with a calm penalty in the 32nd minute, after having been brought down himself by Nathaniel Clyne.
Just before the interval, Philippe Coutinho made it 1-1 with a classy finish.
The goal left United needing three more, and the disjointed, dispirited side of Louis van Gaal never seemed capable of pulling off an improbabe comeback.
Also out are Tottenham, who crashed 2-1 at home to Dortmund for whom Pierre-Emerick Aubameyang scored a handsome brace.
Heung-Min Son scored a late consolation goal for Spurs, who went out on a humbling 5-1 aggregate.
The comeback of the night belonged to Braga, who trounced Fenerbahce 4-1 to go through 4-2.
Shakhtar Donetsk won 1-0 at Anderlecht to cruise through 4-1.
Athletic Bilbao, Villarreal and Sparta Prague reached the quarter-finals of the Europa League at the expense of Valencia, Bayer Leverkusen and Lazio.
Bilbao lost 2-1 to Valencia, who started with Socceroo Mat Ryan in goal, but squeaked through on the away goals rule, with a 2-2 aggregate.
Valencia's exit from Europe's second-tier competition heaps more pressure on under-fire English manager Gary Neville, who was sent off for vehemently protesting against Bilbao's controversial killer goal.
Valencia swept into a promising 2-0 lead but conceded the vital away goal to Bilbao's ageless striker Aritz Aduriz.