Marge and Homer Simpson agree to vote for Hillary Clinton in the forthcoming US election in a new video clip released by 20th Century Fox.
The standalone clip, entitled 3am, has been posted on YouTube.
Republican candidate Donald Trump is seen with a copy of a book called Great Speeches by A. Hitler in the video.
When Homer signals that he might vote for Trump, Marge says: "If that's your vote, I question whether I can ever be with you again."
Homer replies: "And that's how I became a Democrat."
Clinton and Trump are set to face each other in the 8 November US presidential election.
'Not now, I'm on Twitter'
The Simpsons' discussion comes about when Marge says that she "can't make love until I've decided who to vote for".
The narrator then poses the question: "It's 3am and the phone is ringing in the White House - who do you want to answer that call?"
The question is a reference to Hillary Clinton's political campaign of 2008, which ran an ad featuring a ringing phone at 3am, asking Americans who they wanted leading their country during a time of crisis.
Both Mrs Clinton and Mr Trump are then seen responding to such a phone call.
Trump responds by saying: "Not now, I'm on Twitter."
He then orders an aide to: "Put my name on the Lincoln memorial, disband Nato ... and make me some scrambled eggs on gold plates."
Bill Clinton is seen initially answering the phone with: "The situation room? I'll be right there."
His face then falls as he hands the phone to Hillary, saying: "Oh, it's for you."
His wife replies: "Yes, from now on, it's always for me."