28 Oct 2020

Covid-19: Antibodies 'fall rapidly after infection'

6:10 am on 28 October 2020

Levels of protective antibodies in people wane "quite rapidly" after coronavirus infection, say researchers.

Covid-19 coronavirus particles, illustration. The new coronavirus SARS-CoV-2 (previously 2019-CoV) emerged in Wuhan, China, in December 2019.

Illustration of SARS-CoV-2, the virus which causes Covid-19. Photo: AFP

Antibodies are a key part of our immune defences and stop the virus from getting inside the body's cells.

The Imperial College London team found the number of people testing positive for antibodies has fallen by 26 percent between June and September.

They say immunity appears to be fading and there is a risk of catching the virus multiple times.

The news comes as figures from the Office for National Statistics show that the number of Covid-19 deaths in the UK rose by 60 percent in the week of 16 October.

The ONS figures suggest there have now been more than 60,000 deaths involving Covid-19 in the UK.

More than 350,000 people in England have taken an antibody test as part of the REACT-2 study so far.

In the first round of testing, at the end of June and the beginning of July, about 60 in 1,000 people had detectable antibodies.

But in the latest set of tests, in September, only 44 per 1000 people were positive.

It suggests the number of people with antibodies fell by more than a quarter between summer and autumn.

"Immunity is waning quite rapidly, we're only three months after our first [round of tests] and we're already showing a 26 percent decline in antibodies," said Professor Helen Ward, one of the researchers.

The fall was greater in those over 65, compared with younger age groups, and in those without symptoms compared with those with full-blown Covid-19.

The number of healthcare workers with antibodies remained relatively high, which the researchers suggest may be due to regular exposure to the virus.

Antibodies stick to the surface of the coronavirus to stop it invading our body's cells and attacking the rest of the immune system.

Exactly what the antibody drop means for immunity is still uncertain. There are other parts of the immune system, such as T-cells, which may also play a role, directly killing infected host cells and calling to other immune cells to help out.

However, the researchers warn antibodies tend to be highly predictive of who is protected.

Professor Wendy Barclay said: "We can see the antibodies and we can see them declining and we know antibodies on their own are quite protective.

"On the balance of evidence, I would say it would look as if immunity declines away at the same rate as antibodies decline away, and that this is an indication of waning immunity."

There are four other human coronaviruses, which we catch multiple times in our lives. They cause common cold symptoms and we can be reinfected every six to 12 months.

Many people have mild or asymptomatic coronavirus infections.

Two out of every three people who tested positive for coronavirus in a study published today by the Office for National Statistics experienced none of the main symptoms of coronavirus.

Separate figures from the ONS today showed that Covid-19 deaths in the UK increased from just under 500 to just over 750 in the week to 16 October, pushing the total number of deaths 6 percent over the level expected for this time of year.

The ONS figures suggest that more than 60,000 deaths in the UK have involved coronavirus so far this year.

By 16 October, more than 59,000 of these deaths had happened and, since then, a further 1200 people have died within 28 days of a positive test for coronavirus. Ninety percent of these deaths happened before the end of June.

There have been very few confirmed cases of people getting Covid twice. However, the researchers warn this may be due to immunity only just starting to fade since the peak infection rates of March and April.

The hope is the second infection will be milder than the first, even if immunity does decline, as the body should have an "immune memory" of the first encounter and know how to fight back.

The researchers say their findings do not scupper hopes of a vaccine, which may prove more effective than a real infection.

One of the researchers, Professor Graham Cooke, said: "The big picture is after the first wave, the great majority of the country didn't have evidence of protective immunity.

"The need for a vaccine is still very large, the data doesn't change that."

Professor Paul Elliott, director of the REACT-2 study, said it would be wrong to draw firm conclusions from the study about the impact of a vaccine.

He said: "The vaccine response may behave differently to the response to natural infection."

But he said it was possible that some people might need follow-up booster doses of any vaccine that became available to top up fading immunity over time.


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