Men's favourite and defending French tennis Open champion Rafael Nadal could face off at Roland Garros with two fellow Spaniards who have already beaten him on his favourite clay surface, while women's champion Serena Williams was also handed a tricky route.
Eight-times champion Nadal plays American Robbie Ginepri in round one but Nicolas Almagro and David Ferrer are seeded to face him in the fourth round and the quarter-final respectively.
Almagro surprisingly beat Nadal in the quarter-finals of the Barcelona Open while Ferrer, who the Mallorcan beat in last year's French Open final, knocked him out at the same stage at the Monte Carlo Masters.
Defeat by Novak Djokovic in the Italian Open final meant Nadal has lost three matches on the European claycourt swing for the first time in a decade, raising doubts over his form.
Djokovic, chasing the only grand slam title missing from his collection, takes on Portuguese Joao Sousa in the first round en route to a possible semi-final showdown against former world number one Roger Federer.
Fourth seed Federer plays Slovakian Lukas Lacko in the first round while his fellow Swiss Stan Wawrinka, the third seed, faces a tough first round against plays Spaniard Guillermo Garcia-Lopez in round one.
Wawrinka is seeded to meet Nadal in the semi-finals.
Briton Andy Murray, the seventh seed, is on collision course with Wawrinka after a last-eight spot in Rome boosted his confidence following a rough start to the year.
Murray is up against Kazakhstan's Andrey Golubev first up.
Women's holder and world number one Williams was drawn against France's Alize Lim in the first round before a likely quarter-final clash with Russian Maria Sharapova, whom she beat in last year's final.
Seventh seed Sharapova has been improving greatly on clay over the years and won the Stuttgart and Madrid titles this year back to back. She faces a qualifier in round one.
Second seed Li Na of China, winner in 2011, also faces French opposition in round one in the shape of Kristina Mladenovic. World number four Simona Halep of Romania is Li's potential semi-final opponent.
The top half of the women's draw looks tougher than the bottom with Wimbledon runner-up Sabine Lisicki, Australian Samantha Stosur and third seed Agnieszka Radwanska lurking.