Chelsea's perfect start to the season under new manager Carlo Ancelotti came to a surprise end when the Premier League leaders lost 3-1 at Wigan Athletic and had goalkeeper Petr Cech sent off.
Titus Bramble headed Wigan in front before Didier Drogba equalised just after half-time but Cech was shown a red card for bringing down Hugo Rodallega and the Colombian fired his penalty past Cech's replacement Hilario. Paul Scharner scored Wigan's third goal in stoppage time.
Chelsea, who had won their first six league games of the season, slipped below Manchester United on goals scored after the champions won 2-0 at Stoke City.
There were big wins for Liverpool and Tottenham Hotspur who occupy third and fourth spots. Fernando Torres hit a hat-trick for Liverpool in a 6-1 thrashing of Hull City and Robbie Keane scored a hat-trick for Spurs in a 5-0 defeat of Burnley.
Aston Villa lost 2-1 at Blackburn Rovers while Portsmouth are still pointless at the bottom of the table after losing 1-0 at home to Everton.