Fulham and Cardiff City were relegated from English football's Premier League after defeats in their penultimate games of the season left them unable to reach safety.
Fulham's 13-year run in the English top flight was ended by a 4-1 defeat at Stoke City, while Cardiff went straight back down to the Championship following a 3-0 loss at Newcastle United.
Both sides' fates were sealed by fourth-bottom Sunderland's unexpected 1-0 win at Manchester United, which took Gus Poyet's side four points above Fulham and five points clear of bottom club Cardiff.
Sunderland can secure their own survival by winning their game in hand at home to West Bromwich Albion on Thursday, although they will effectively be safe if Norwich City lose at Chelsea tomorrow.
United's defeat means that Tottenham Hotspur remain in pole position to secure sixth place, and with it Europa League qualification, despite having lost 2-0 at West Ham United earlier in the day.
Spurs continue to lead United by six points, having played a game more.
Elsewhere, Andreas Weimann scored twice as Aston Villa won 3-1 at home to FA Cup finalists Hull City, while Southampton striker Rickie Lambert scored a 93rd-minute winner in a 1-0 victory at Swansea City.