The Brisbane City Council bus mounted the curb on Melbourne Street and crashed into the front of the Punjabi Palace Indian restaurant at about 4.40pm (AEST) on Saturday.
A Queensland Ambulance Service spokeswoman told AAP that no passengers were on the bus and no customers were in the restaurant at the time.
She said paramedics assessed 10 people at the scene for injuries, including the driver, and three people were taken to hospital with minor injuries.
The front of the restaurant was extensively damaged by the bus which wedged underneath an awning.
