The Springbok coach Heyneke Meyer has made five changes from the side that lost to Ireland fo this weekend's clash with England at Twickenham.
Significantly, halves Cobus Reinach and Pat Lambie - who both came off the bench in the 29-15 loss to Ireland in Dublin last weekend - have been named to start, with halfback Francois Hougaard and first-five Handre Pollard, the men they came on for at Lansdowne Road, among the replacements named.
In the other changes, World Cup-winners JP Pietersen and Schalk Burger have been brought in at right wing and openside flanker respectively, with Adriaan Strauss taking over at hooker from Bismarck du Plessis.
The five changes to the team are straight swaps between the starting line-up and the bench in Dublin.
Meyer says they've accepted their performance against Ireland last weekend was not up to scratch and everyone in the touring squad has put up their hands and dug deep this week.
England, who launched their November programme with a 24-21 loss to New Zealand, are due to name their team tonight.
Team: 15-Willie le Roux; 14-JP Pietersen, 13-Jan Serfontein, 12-Jean de Villiers (captain), 11-Bryan Habana, 10-Pat Lambie, 9-Cobus Reinach, 8-Duane Vermeulen, 7-Schalk Burger, 6-Marcell Coetzee, 5-Victor Matfield, 4-Eben Etzebeth, 3-Jannie du Plessis, 2-Adriaan Strauss, 1-Tendai Mtawarira
Replacements: 16-Bismark du Plessis, 17-Trevor Nyakane, 18-Coenie Oosthuizen, 19-Bakkies Botha, 20-Teboho Mohoje, 21-Francois Hougaard, 22-Handre Pollard, 23-Cornal Hendricks.