Wallabies coach Ewen McKenzie has run out of patience with misfiring playmakers Kurtley Beale and Nic White, dumping them to the bench for Saturday's Test against South Africa in Perth.
Replacing them are the New South Wales Waratahs players Bernard Foley and Nick Phipps.
Adam Ashley-Cooper shifts out to the wing following Pat McCabe's career-ending neck injury, while Tevita Kuridrani is the new centre, while James Hanson comes in for injured hooker Nathan Charles.
Former captain and lock James Horwill replaces the hulking Will Skelton on the bench.
Australia: 15-Israel Folau, 14-Adam Ashley-Cooper, 13-Tevita Kuridrani, 12-Matt Toomua, 11-Rob Horne, 10-Bernard Foley, 9-Nick Phipps, 8-Wycliff Palu, 7-Michael Hooper (captain), 6-Scott Fardy, 5-Rob Simmons, 4-Sam Carter, 3-Sekope Kepu, 2-James Hanson, 1-James Slipper
Replacements: 16-Saia Faingaa, 17-Pek Cowan, 18-Ben Alexander, 19-James Horwill, 20-Scott Higginbotham, 21-Matt Hodgson, 22-Nic White, 23-Kurtley Beale