Levi Leipheimer has pulled out of the Tour de France with a fractured wrist.
His Astana team says Leipheimer has a transverse fracture of the right scaphoid, a small bone in the wrist.
The American, who was fourth overall, crashed towards the end of Thursday's 12th stage.
His Astana team-mates Alberto Contador and Lance Armstrong are second and third behind Rinaldo Nocentini.