Ana Ivanovic has lost her chance to defend her French tennis Open crown, losing in straight sets to the Belarussian teenager Victoria Azarenka in round four.
Serbian Ivanovic struggle with a right knee injury since last year's victory at Roland Garros has seen her world ranking slip from number one to eighth.
The ninth-seeded Azarenka will meet world number one Dinara Safina in the quarter-final.