The Argentina first five Juan Martin Hernandez will make his first test appearance for his country in three years in the Rugby Championship match against South Africa at Newlands this weekend.
The 30-year-old has suffered a string of injuries since helping his country finish third at the 2007 World Cup.
His last test was against England in June 2009.
The team will be captained by number eight Juan Martin Fernandez Lobbe who takes over from Felipe Contepomi after the centre made himself unavailable for this tournament.
The starting team includes 14 players who play in Europe, with only flanker Julio Farias Cabello playing in Argentina.
Twelve of the team took part in last year's World Cup in New Zealand.
Team - Lucas Gonzalez Amorosino; Gonzalo Camacho, Marcelo Bosch, Santiago Fernandez, Horacio Agulla; Juan Martin Hernandez, Nicolas Vergallo; Juan Martin Fernandez Lobbe (captain), Alvaro Galindo, Julio Farias Cabello, Patricio Albacete, Manuel Carizza, Juan Figallo, Eusebio Guinazu, Rodrigo Roncero.
Replacements - Bruno Postiglioni, Marcos Ayerza, Juan Pablo Orlandi, Thomas Leonardi, Leonardo Senatore, Martin Landajo, Martin Rodriguez.