The only carrier servicing the Northern Marianas-Guam route has cancelled its services indefinitely to ensure technical issues with its aircraft are fixed.
Cape Air's president, Linda Markham, says it hopes to have the aircraft return to service as soon as possible.
Ms Markham says while flight cancellations are an inconvenience to customers, Cape Air will not sacrifice the safety of its passengers.
This announcement comes after Cape Air cancelled 13 flights over the weekend.
Due to cancellations, Cape Air has asked for the help of code share partner United Airlines to accommodate stranded passengers in Guam.